Page 5 - Scientific Library
Specific cytokines & growth factors in... neurobiology!
Neurobiology is the study of cells of the nervous system and their organization into functional circuits that process information and mediate behavior.
Neurotrophic factors
Neurotrophic factors are
5 new research tools to perform chromatin and epigenetic analysis
Nucleosomes are core particles involved in DNA packaging in eukaryotic cells. They affect gene expression levels  by regulating access of DNA to transcription factors and DNA binding proteins.
Why multiplex histone binding arrays?
In the summer of 2013, my colleague Frederic Dubor, who is in charge of our services lab, mentioned to me that he had just been asked by 3 clients within a very short time-frame, whether our laboratory
Site-specific modified-histone substrates
Recombinant Histone proteins are popular research solutions in Drug discovery and Epigenetics studies. They can be used as in vitro positive controls in the analysis of post-translational Histone modifications,
Epigenetics Writers - Readers - Erasers: Targeting Writers in Drug Discovery
Epigenetic modifications target DNA and Histone proteins.
One of the roles of Epigenetics is to drive cellular differentiation from totipotent Stem cells to fully differentiated cell types, by regulating
H3K4me3 Histone Demethylase Fbxl10 Activity Assay
The Histone Demethylase FBXL10 (also known as NDY1, KDM2B, or JHDM1B) has been reported to demethylate histone H3K4me3.  By removing active Methyl Epigenetic marks on the chromatin, this "Epigenetic
Sircol for soluble and insoluble collagen assays!
Measuring soluble collagen in biological samples is a straightforward experiment which can be done with the Sircol soluble collagen assay using Sirius Red dye (Sircol dye) in a convenient manner (we explored
Writing - Erasing - Reading Epigenetics: Targeting Erasers in Drug Discovery
DNA and Histone proteins are targets for epigenetic modifications.
One of the roles of Epigenetics is to drive cellular differentiation from totipotent Stem cells to fully differentiated cell types,
8 new JARID1 - JMJD2 HMT assays
A lot of efforts are made to identify potent and selective inhibitors for the demethylation reactions catalyzed by members of the JMJD2 and JARID1 protein families (1, 2). Both epigenetic eraser enzyme
Epigenetics Writers - Readers - Erasers: Targeting Readers in Drug Discovery
DNA and Histone proteins are targets for epigenetic modifications. While DNA is only methylated, histones can be targets for diverse modifications such as methylation, acetylation, ubiquitination, phosphorylation
HSCI's researchers switch skin cells into pain-sensing neurons
In a recent publication, Dr Clifford J. Woolf's
Fluorescent ShK toxin for Kv1.3 ion channels
Kv1.3 channels are expressed in T-cell lymphocytes and over-expressed in autoimmune diseases. They can be see as a therapeutic taget for T cell mediated autoimmune diseases.
ShK toxin (Stichodactyla helianthus