Page 5 - Scientific Library

In a previous post I discussed 3 new unique research tools

Introduction

Hepatic stellate cells (HSC, also known as perisinusoidal cells or Ito cells), are liver-specific mesenchymal cells found in the space of Disse. HSC maintain interactions with

Paez-Gonzalez et al. (Duke University) have discovered a new population of choline acetyltransferase (ChAT)+ neurons present in the rodent subventricular zone (SVZ). (1) This niche is known

Kupffer cells are macrophages endogenous to the liver which have the ability to modulate hepatic inflammation and injury associated with various pathophysiologies and toxicities. Pro-inflammatory cytokines

Neurobiology is the study of cells of the nervous system and their organization into functional circuits that process information and mediate behavior.

Neurotrophic factors

In a recent publication, Dr Clifford

Kv1.3 channels are expressed in T-cell lymphocytes and over-expressed in autoimmune diseases. They can be see as a therapeutic taget for T cell mediated autoimmune diseases.

Assessing gene transcription as an endpoint for determining induction of drug metabolizing enzymes and transporters has become the “method of choice” in the FDA’s latest draft Guidance for Industry drug

Neurotrophins are important biomarkers in Neurobiology, including stem cell development to neural lineages. BDNF and NGF are the ones being studied in most cases. However, it has been found that neurotrophins

A wide range of in vitro models are used in preclinical drug testing for the investigation of ADME-Tox (Absorption, Distribution, Metabolism, Excretion and oxicity) properties of New Chemical

ELISAs are widely used in biomarker-related studies, especially when a high number of samples is involved, and only a few biomarkers need to be quantified. That said, incubations can be somehow cumbersome,