Page 12 - Scientific Library
Focus on the JAK-STAT pathway...
The Janus kinase (JAK) / Signal Transducer and Activator of Transcription (STAT) pathway a key regulator of cellular proliferation, differentiation, migration, apoptosis and survival. Numerous cytokines,
IP3-mediated STIM1 oligomerization requires intact mitochondrial Ca2+ uptake by Deak et al.
Deak AT et al. decipher the mechanisms by which mitochondria contribute to Ca2+ intracellular signaling. In their recent paper (1), they show that mitochondrial "Ca2+ buffering" close to the Endoplasmic
Distinctions between homogeneous bulk cancer cell tumors vs. Cancer Stem cell driven tumors by Pr. Clarke
Professor Alan Clarke, (Director of the European Cancer Stem Cell Research Institute) has recently given an overview of how Cancer Stem cell tumors differ from the conventional "homogenous bulk cancer
Focus on the Hypoxia Pathway...
Hypoxia in tumors is closely associated with tumor aggressiveness and resistance to radio- and chemotherapeutic treatment. Therefore, reliable markers for hypoxia represent both valuable diagnostic markers
How to measure Calcium in cell based assays?
In Pharma screening departments there is a strong need for Ca2+ measurement methods.
Why is this?
GPCRs (G Protein Coupled Receptors) are still major targets of pharmaceutical screenings.
Around 30-40%
Immunotherapy Screening - B7-1 / CD28 and B7-1 / CTLA4 Pathways in Drug Discovery
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
Immunotherapy Screening - A focus on PD-1/PD-L1/PD-L2 Pathway in drug discovery
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
5 new research tools to perform chromatin and epigenetic analysis
Nucleosomes are core particles involved in DNA packaging in eukaryotic cells. They affect gene expression levels  by regulating access of DNA to transcription factors and DNA binding proteins.
Why multiplex histone binding arrays?
In the summer of 2013, my colleague Frederic Dubor, who is in charge of our services lab, mentioned to me that he had just been asked by 3 clients within a very short time-frame, whether our laboratory
New hope for Ras inhibitors
Ras belongs to the family of small G-proteins and plays an important role in several signal transduction pathways involved in normal cell growth and differentiation. Over 30 years ago three isoforms of
Immunotherapy - BLTA:HVEM, CD47:SIRPα in drug discovery
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
Site-specific modified-histone substrates
Recombinant Histone proteins are popular research solutions in Drug discovery and Epigenetics studies. They can be used as in vitro positive controls in the analysis of post-translational Histone modifications,