Page 7 - Scientific Library

Ion channels play an important role in perception and transmission of pain sensations. Furthermore, dysfunctions of certain ion channels are involved in neuronal disorders, such as epilepsy, Alzheimer's

G Protein Coupled Receptors (GPCR) and ion channels are important targets in drug development. Both target classes represent membrane proteins which require convenient and robust cell-based assays for

For one year now,  SiR-Actin and SiR-Tubulin, the second generation of tools to stain actin and tubulin in living cells, have been available on the market - and although it may sound like an overstatement,

In their most recent publication "SiR-Hoechst,

Statins are HMG-CoA reductase inhibitors, well-known  medications for treating Hypercholesterolemia. Simvastatin is a member of this "Statin family" and controls

PGE₂ is a potent lipid mediator involved in maintaining homeostasis but also in the promotion of acute inflammation or immune

Thousands of researchers spend time pampering their primary cells and cell lines every day, with the aim of defining their optimal cell culture conditions. Researchers are in effect trying to control

Classically, it was known that CD4⁺ T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions to effect the

Immunoediting of cytokine signals provides another area of pathways which tumours utilise to evade and potentially escape from immunological targeting. This post aims at shedding some light into the

Histone Methyltransferases (ex. EZH1 and EZH2, and G9a) and their counter-parts (Histone demethylases like JARID1, the KDM4, and the JMJD family) have become promising targets for inhibitor screenings,

Visualizing fixed cells and tissues only gives snap shots of cellular processes. Over the past years, more and more cellular parameters

In a previous post, we looked at the importance of sample preparation methods depending on the biomarker being studied (e.g. MMPs, cytokines). Today, let's focus on cell / tissue lysates.

Tip #1