Page 7 - Scientific Library
How to activate or inhibit autophagy?
The term Autophagy was introduced by Christian de Duve during the Ciba Foundation Symposium on Lysosomes – which was held in London in February 1963. In 1974 he was honoured with the Nobel price in
How to choose the perfect buffer to get a pure, stabilised, functional protein
Protein biochemistry brings together a vast and varied world of methods of protein production, purification and characterization. Once you have successfully achieved the production of your protein in a
How to combine advantages of ELISAs and Arrays - Target validation with Quantibody®
On your journey to Biomarker profiling, you will reach the point where you need to quantify the proteins of interest identified along the way (eg. validation of semi-quantitative array results; biomarker
Stauprimide inhibits c-myc transcription in cancer cells
Stauprimide is known to prime Embryonic Stem Cells (ESC) by targeting the c-Myc-activating transcription factor NME2. Its mechanism of action is linked to the inhibition of the nuclear localization of
3 novel PD-L1 post-translational modifications identified
In a recent paper, Horita H. et al. identified a set of novel Post-Translational Modifications (PTMs) of the protein Programmed Cell Death Ligand (PD-L1).
How to optimise your recombinant protein purification and protein production
Undoubtedly, producing and purifying a protein is an art form.
Indeed, each recombinant protein (rec. protein) to be produced in vitro has specific characteristics and singularities, which makes its production
Bioactive neuronal lipid mediators: a focus on Synaptamide
Focus Biomolecules produces a broad range of bioactive lipid mediators as well as many small molecule inhibitors of numerous lipid metabolic pathways for use as cellular probes. These can be supplied
GPR17 and Remyelination: activators and antagonists
The absence of mature oligodendrocytes for the repair of demyelination lesions is a critical factor in the pathology of Multiple Sclerosis (MS), and other debilitating CNS disorders of myelination. As
Tips and Tricks - Protein purification and production for LC-MS characterization
Mass spectrometry is a technology which is widely used in most scientific disciplines that require accurate and precise measurement of elemental and molecular components. Its use in the pharmaceutical
4 Tips to boost mRNA in vitro transcription and optimize mRNA delivery
Over the last years, mRNA-based experimental approaches have been successfully used in a broad range of research applications (genome editing, gene replacement, vaccine, immunotherapy, cellular reprogramming...)
Where to find antigens and antibodies for Enterovirus-specific Assay development
Enteroviruses are common human viruses causing rather mild symptoms. However many different species and serotypes (incl. Echoviruses, Polioviruses, Coxsackieviruses A and B) can cause serious illness