Page 4 - Scientific Library
How to probe motor-domains of kinesins?
In the past, molecular motor proteins like kinesins have been investigated with macromolecular approaches. Recent research on kinesins has been focused on resolving how kinesin is regulated by intramolecular
Growth factors in cartilage biology and osteoarthritis
Cartilage is a flexible connective tissue which can rapidly grow and which is specialized to absorb and resist compression. The perichondrium, a vascularized layer, surrounds the tissue which does not
New tools to fight against Pneumococcus
Pneumococcus, or scientifically speaking, Streptococcus pneumoniae, is a pathogen responsible for a number of illnesses, including pneumonia, ear infections, sinus infections, meningitis and bacteremia.
Epigenetics Writers - Readers - Erasers: Targeting Readers in Drug Discovery
DNA and Histone proteins are targets for epigenetic modifications. While DNA is only methylated, histones can be targets for diverse modifications such as methylation, acetylation, ubiquitination, phosphorylation
Immunotherapy Screening - GITR:GITRL pathway
In previous blogs, I invited you to read about the relevance of the B7-1 : CD28, B7-1 : CTLA4, the BLTA:HVEM, CD47:SIRPα , and the PD-1/PD-L1/PD-L2 pathway for immunotherapy screenings and discussed
Novel biomarkers for esophageal cancer
As discussed in previous posts, use of new tools allows the finding of new disease-related biomarkers. Today, we want to put our spotlight on esophageal cancer.
A recent alliance between Quansys Biosciences
AAV - advantages for Gene delivery in vivo
Adenoassociated viruses (AAV) are small (20-30 nm), ssDNA, non-enveloped and replication-defective viruses that infect human and other primate species, but which, up to now, have not been reported as being
Novel biomarkers in gastric cancer
The word "cancer" groups a series of diseases of different origin and different prognosis, with differentiated molecular mechanisms causing their onset and progression. Hence, discovery of novel biomarkers
Next generation of lentiviral particles
Lentiviruses are robust tools for cell line engineering and development. As opposed to models that only infect dividing cells, lentiviral vectors are ideal for long term gene delivery into dividing and
Tumour microenvironment - ameloblastomas
Following our post on tumour microenvironment and glioblastoma, we will focus today on ameloblastomas.
Ameloblastomas are benign tumours that occur in the jawbone, and invade bone. This type of tumour
Exosomes as a trigger for signaling
Extracellular vesicles in general, or exosomes in particular, are becoming a hot topic for research, especially in cancer. They seem to have different roles in tumour progression or can be used as
Adenovirus: weapons of mass transduction for gene delivery
Adenovirus (AV) are non-enveloped and non-integrative icosaedral viruses. Recombinant AV (genetically modified with respect to the wild-type in order to lose their capacity of replication) are widely used