Page 6 - Scientific Library
Growth factors in cartilage biology and osteoarthritis
Cartilage is a flexible connective tissue which can rapidly grow and which is specialized to absorb and resist compression. The perichondrium, a vascularized layer, surrounds the tissue which does not
miRNA mediates gene expression through HDL particles
A recent study published in Nature Communications is the first to report how a mature microRNA (miR-223) actively controls the gene expression of a cell in which it was not originally transcribed. High
Tumour microenvironment and miRNA biomarkers
In previous posts, we have seen the role of inflammation and glycosylation in the tumour microenvironment (TME). All these are mainly factors at the protein level causing the tumour cells to evade the
Epigenetics Writers - Readers - Erasers: Targeting Readers in Drug Discovery
DNA and Histone proteins are targets for epigenetic modifications. While DNA is only methylated, histones can be targets for diverse modifications such as methylation, acetylation, ubiquitination, phosphorylation
Glycosylation studies in the inflammasome
In a previous post on tumour microenvironment (TME) and glycosylation, we indicated that new tools for studies on glycosylation of proteins were being developed. We are happy to announce that they are
Immunotherapy Screening - GITR:GITRL pathway
In previous blogs, I invited you to read about the relevance of the B7-1 : CD28, B7-1 : CTLA4, the BLTA:HVEM, CD47:SIRPα , and the PD-1/PD-L1/PD-L2 pathway for immunotherapy screenings and discussed
Physioxia or Hypoxia: what it's all about
Cell culture under oxygen controlled conditions: an improvement towards more predictive results
Oxygen concentration in tissues is a key factor for cell and organ survival. In normal conditions, partial
Direct access to Biomarker Profiling identification tools
Profiling tools have an increasing interest for identifying new biomarkers. Different tools are available, from classical gene profiling on DNA chips, RT-qPCR arrays, Protein arrays for secretome or
What's new in qPCR?
We know molecular biologists spent a lot of time setting up their qPCR protocols and aren't about to change the way they do things. We also know they are technically savvy and like keeping up
Alternatives to the "mega-brands" of molecular biology
If you don't buy luxury brand clothes, why are you still buying luxury brand molecular biology kits?
Let me guess... you might use those blue and red boxed Qiagen® kits for DNA and RNA purification,
Discovery of functional serum biomarkers
Lung cancer is one of the most common malignancies, and the leading cause of cancer-related fatality. Current diagnostic practices for common cancers rely heavily on imaging technologies. These