Page 3 - Scientific Library
20S Proteasome inhibitors and Leptin against obesity
The World Health Organization (WHO) estimated in 2008 that 1.4 billion adults worldwide were overweight and of these 500 million were obese with risks for developing type 2 diabetes, hypertension and cardio-vascular
Pharmacological agents which alleviate Pain
Chronic pain of varying types including inflammatory pain, cancer pain and neuropathic pain is an increasing health problem for which there are inadequate therapeutic options.
Many new targets for
Interferons - the first line of defense against viral infections
Interferons (IFNs) are low molecular weight proteins that belong to the class of glycoproteins known as cytokines. IFNs are part of the non-specific immune system and are an important first line of defense
O-Glucuronide synthesis made easy
6 popular Microtubule agents used in in vitro tubulin assays
Microtubules are key components of the cytoskeletal structure of eukaryotic cells.
How to modulate ion channels
Ion channels play an important role in perception and transmission of pain sensations. Furthermore, dysfunctions of certain ion channels are involved in neuronal disorders, such as epilepsy, Alzheimer's
Neuromuscular diseases: A new application for Statins?
Statins are HMG-CoA reductase inhibitors, well-known medications for treating Hypercholesterolemia. Simvastatin is a member of this "Statin family" and controls
Which Histone (De)Methyltransferase modulators to choose?
Histone Methyltransferases (ex. EZH1 and EZH2, and G9a) and their counter-parts (Histone demethylases like JARID1, the KDM4, and the JMJD family) have become promising targets for inhibitor screenings,
How sample preparation can affect your biomarker studies (II)
In a previous post, we looked at the importance of sample preparation
Montelukast improves learning & memory in aging brain
Montelukast is a marketed drug used for asthma treatment and to relieve symptoms of seasonal allergies. It is known to function as a leukotriene receptor antagonist.
Ion Channels and Cancer Immunology
Ions channels are pore-forming membrane proteins that control ion transit across the cell membrane to various stimuli. It was shown that deregulation or dysfunction of channels are clearly linked to many
CBR-5884 - a Serine biosynthesis inhibitor for cancer research
Metabolic pathways are upregulated in cancer cells to promote their growth and proliferation. The evidence pointing to the requirement of the amino acid serine in tumorigenesis is overwhelming. Serine