Page 10 - Scientific Library

In a recent post, I concentrated on the role of HDACs in cancer: Histone Deacetylases (HDACs) and Cancer and mentioned that some HDACs are overexpressed and show very high activities in

You suspect your protein binds to microtubules? That it might stabilize or destabilize these filamentous structures? Then this post is here to help you to find a meaningful assay to validate your assumption.

Visualizing fixed cells and tissues only gives snap shots of cellular processes. Over the past years, more and more cellular

While it is likely that all Ubiquitin-Like proteins (UBLs) will be important for drug discovery because of these associations, Ubiquitin has been the most completely validated for this

Tumour immune evasion can be mediated by a complex set of interaction involving p53, miR-34 and PDL1. This is the conclusion of a work by Cortez et al. and recently published in JCNI .

The

Recently, I issued a post about a method which allows measuring microtuble binding capabilities of proteins of interest

Deubiquitylating enzymes (DUBs) are promising therapeutical targets, especially in oncology (see my previous post dedicated to this topic). Today, I'd like

The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to

Transporters have become increasingly important in drug development due to the major role they play in absorption, distribution and excretion of

Knowledge about which epitopes are recognized by a blocking antibody can help researchers to develop

Early in 2015, researchers of The University of Queensland Diamantina Institute (Australia) have shown a very sensible approach to the discovery of new biomarkers associated to transition from non-metastatic