Page 3 - Scientific Library

Chronic pain of varying types including inflammatory pain, cancer pain and neuropathic pain is an increasing health problem for which there are inadequate therapeutic options.
Many new targets for analgesic

Nucleosomes are basis units of DNA packaging in eukaryotic cells. A core particle (mono-nucleosome) consists of a segment of DNA called core DNA (147 bp in length)

Acid-Sensing Ion Channels (ASICs) are neuronal voltage-insensitive cationic channels which are activated by extracellular protons. They belong to the ENaC/Deg superfamily of ion channels. Up to now 6

Cord blood might be a much-needed solution. 

Few diseases stump researchers as much as Alzheimer’s disease. Quite simply, nothing has worked beyond some symptomatic relief. On top of that, scientists

In previous posts,  I invited you to look at versatile methods to

• Visualize actin: Focus on Actin staining and visualization
• Measure actin binding: Focus on Actin – Detection of actin binding and

Ion channels are proteins with pore-forming abilities. Their selective capabilities to let ions cross the cell membrane involves them in crucial cellular functions (controlling membrance potential, the

In a recent post on  Venomous toxin ion channel modulators, we looked at toxin derived peptides to manipulate a wide variety of ion channels. These toxins can be used as tools to characterize

Ion channels play an important role in perception and transmission of pain sensations. Furthermore, dysfunctions of certain ion channels are involved in neuronal disorders, such as epilepsy, Alzheimer's

Statins are HMG-CoA reductase inhibitors, well-known  medications for treating Hypercholesterolemia. Simvastatin is a member of this "Statin family" and controls

Analysis of neuronal cell fates and biological activities sometimes relies on the effective staining of a protein of interest (a.k.a. marker) with a specific primary antibody validated for immuno-assays.

Microbial metabolites are a source of unequalled elements for in vitro assays. Sometimes  neglected, these active molecules naturally provide a large spectrum of structural diversity for Drug discovery

First at all, a quick reminder... Cytokines play important roles in inflammation, innate immunity, angiogenesis and cell growth. They are involved in a lot of disease processes like cancer, obesity and