Page 14 - Scientific Library

Following on from my previous post  in which I started to introduce a series of techniques to investigate the impact of miRNA expression on cell fate, let's take a look at the first one: miRNA detection

In this third post of the miRNA-related series, let's take a look at miRNA overexpression.

miRNA mimics

Short RNAs are very prone to enzymatic degradation. Novel chemical technologies now allow RNA stabilization

In a recent publication, Gole B. and Baumann C. demonstrate the role of the apoptotic nuclease EndoG in Mixed-Lineage Leukemia breakpoint cluster region (MLLbcr) destabilisation leading to MLL gene

Following on in our series on microRNAs (miRNA - Keys to open cell biology’s secret chamber) , in this post, we'll be taking a look at Antagomirs (which are also called anti-miRs or blockmirs). These

Human Newborn Foreskin Fibroblasts (NuFF cells) are genuine feeder cells for Stem cell research. Mitotically inactive NuFF cells (by irradiation or Mitomycin C chemical treatment) can efficiently maintain

Leading on from my previous posts (see below) exploring microRNA detection, overexpression and inhibition, this time, let's spend a moment on target detection.

miTarget databases

There are many online

Antibody pairs have been used for years to detect biomarkers in biological samples. They are a convenient and price-wise alternative to ready-to-use ELISAs, especially when they are used on a routine basis

The cellular and physiological effects resulting from hypoxia-dependent networks have been clearly shown to impact a number of human pathological states, including ischemic disease, diabetes, pulmonary

Several lines of evidence show that synthetic lethal interactions targeting DNA repair pathways may have clinical applications in cancer therapy. In a recent paper, Albarakati et al. demonstrate that

In a previous post on Cellular Matrices for Translational Research, I introduced HyStem hydrogels.  In order to engineer a custom culture system with HyStem, simple pilot studies or optimization

In vivo monitoring of tumor growth and metastasis provides a powerful means for studying cancer properties and development of effective therapies. Mouse models created with tumor xenografts, resulting