Page 11 - Scientific Library
Fluorescent ShK toxin for Kv1.3 ion channels
Kv1.3 channels are expressed in T-cell lymphocytes and over-expressed in autoimmune diseases. They can be see as a therapeutic taget for T cell mediated autoimmune diseases.
MDR1 activity enhancement reduces senescence markers
During the last International Federation of Societies of Cosmetic Chemists (IFSCC) congress (Paris, Oct. 2014), Hajem N. et al (ALES Groupe) have shown that by enhancing MDR activity of fibroblasts
Immunotherapy Screening - CD40:CD40L pathway
In my previous blogs, I invited you to read about the relevance of the B7-1
Immunotherapy Screening - CD137:CD137L pathway
In previous blogs, I invited you to read about the relevance of the B7-1
Predicting CYP induction in stable cell lines
Assessing gene transcription as an endpoint for determining induction of drug metabolizing enzymes and transporters has become the “method of choice” in the FDA’s latest draft Guidance for Industry drug
PBMCs & drug development
Use of human samples including peripheral blood mononuclear cells (PBMCs) in drug discovery is critical for increasing the chances of success for a small molecule screen hit. A review based on recent published
Erythropoietin - active EPO for... hematologists!
EPO has a reputation with many non-scientists through bad press in the cycling/racing environment. From a researcher's point of view, Erythropoietin or EPO is a 34 KDa glycoprotein known as the
HD-LCI video of HUVEC Transfection with Cytofect Kit
See human cells glow with green fluorescent protein in this time-lapse video. These images were captured over 20 hours via Lumascope 620.
[youtube https://www.youtube.com/watch?v=k5esUe_rrr4]
Hepatic Cellular Models
A wide range of in vitro models are used in preclinical drug testing for the investigation of ADME-Tox (Absorption, Distribution, Metabolism, Excretion and oxicity) properties of New Chemical
E3 Ligases: RING- or HECT-mediated ubiquitination?
A large number of cellular processes are regulated by the reversible conjugation of Ubiquitin (UB) proteins to substrates. UB-related research tools (including E1-, E2 and E3 Ligases) are now commercially available
Cellular models for studying the human urogenital system
The urogenital system is the organ system of the reproductive organs and the urinary system. These are grouped together because of their proximity to each other, their common embryological origin and the