ORF expression in Mammalian cells is very useful for many applications: protein production with HEK293, over-expression of tagged protein for immuno-tracking or immuno-precipitation, development of a cell

Gene knock-out, which is gene editing leading to loss of function, just requires delivering into cells the 2 CRISPR system actors: the CAS9 endonuclease and the specific guide RNA to target

Real time visualization of cellular events by Live Cell Imaging (LCI) has led to a better understanding of the global dynamic biological process. In a constantly evolving field, tebu-bio

This month, a new leap forward in gene editing has been published in Nature under the title 'Search-and-replace genome editing without double-strand breaks or donor DNA'. DOI: 10.1038/s41586-019-1711-4.

Following on from the popular SiR-Probes, earlier this year Spirochrome introduced new SPY probes, as presented in

Despite its importance in the regulation of many cellular processes, membrane tension is still complicated to measure. And despite valuable insights, the techniques currently available remain complex and

With the great success of the SIR-probes for efficient labeling of the cell Cytoskeleton, DNA and Lysosome, Spirochrome have just

Our body is made up of trillions of cells grouped together to form tissues and organs. The genes present in the nucleus of every cell tell it when to grow, work, divide and die.

Normally, our cells

In medicine, biotech and pharmacology, drug discovery is the entire process to discover new candidate medications.

The process is long and complex, the budget needed is expansive and the skills

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

In their latest publication in Nature, Dr. Moiseeva et.al., studied cellular senescence in skeletal

Genes are key components of our lives. With many other factors, they contribute to shaping us, making people and any other living organism what they are. Genomes, whether human or not, are able

Mitochondrial Dynamics and Mitochondria-Lysosome Contacts in Neurogenetic Diseases

In an article published in frontiers in Neuroscience, with the aim to study cellular phenotypes