Page 9 - Scientific Library
Stellate cells - models for liver studies
Introduction
Hepatic stellate cells (HSC, also known as perisinusoidal cells or Ito cells), are liver-specific mesenchymal cells found in the space of Disse. HSC maintain interactions with
1 simple way to rapidly quantify Collagen: Sircol Collagen Assay
Collagen is a structural protein expressed in mammalian tissues (ex. skin, muscles, tendons, ligaments, cartilages, blood vessels...). Together with Elastin and Keratin, Collagen fibres give connective
How to select Hyaluronic Acid (HA) quantitative tests?
Hyaluronic acid (also called HA or Hyaluronan) is a glycosaminoglycan with unique characteristics. HA possesses elevated viscosity, enabling tissues (eye, skin, joint and synovial fluid...) to resist
Recent advances in Stem Cell culture: Encapsulated Stembeads growth factors
During my daily discussions with researchers involved in in vitro iPS and Embryonic Stem cell cultures, I am always amazed by the passion that drives them. However, the more I go in depth with
Primary cell sourcing: Cryopreserved Human Adult Sebocytes
Sebocytes are emerging cellular models to study skin biology but also to design new compounds to regulate acne, seborrhoea and other sebaceous gland-related diseases. Easy access to cryopreserved and well-qualified
Modulate hepatic inflammation
Kupffer cells are macrophages endogenous to the liver which have the ability to modulate hepatic inflammation and injury associated with various pathophysiologies and toxicities. Pro-inflammatory cytokines
Human Primary Sebocyte assay for compound testing on lipid metabolism
Sebocytes belong to the epidermal ecosystem together with hair follicules or in sebaceous glands. Sebocytes play a key role in skin health by producing sebum. These cells are now at the center of researchers'
Sircol for soluble and insoluble collagen assays!
Measuring soluble collagen in biological samples is a straightforward experiment which can be done with the Sircol
MDR1 activity enhancement reduces senescence markers
During the last International Federation of Societies of Cosmetic Chemists (IFSCC) congress (Paris, Oct. 2014), Hajem N. et al (ALES Groupe) have shown that by enhancing MDR activity of fibroblasts
Predicting CYP induction in stable cell lines
Assessing gene transcription as an endpoint for determining induction of drug metabolizing enzymes and transporters has become the “method of choice” in the FDA’s latest draft Guidance for Industry drug
5 reasons to prefer custom rec. protein production to commercial
Many recombinant proteins (rec. proteins) are now commercially available. And many of them, mainly secreted soluble proteins, are biologically active, so there shouldn't be any need to look for alternatives