Page 6 - Scientific Library
IDO and TDO - Cell based & biochemical assays
Which roles do IDO and TDO play in Immunotherapy? Immune evasion is one of the identifying hallmarks of cancer and researchers are investigating the complex mechanisms that enable cancer
Immunotherapy Screening – OX40:OX40L pathway
The treatment of diseases by inducing, enhancing, or surpressing an immune response is referred to as Immunotherapy. T-cell activation and inactivation requires the coordination of various co-inhibitory
Neuromuscular diseases: A new application for Statins?
Statins are HMG-CoA reductase inhibitors, well-known medications for treating Hypercholesterolemia. Simvastatin is a member of this "Statin family" and controls
A new fast and sensitive PGE2 Immunoassay kit
PGE2
3 easy colorimetric assays to measure ECM components
Matrix components are key R&D elements in pharmaceutical and cosmetology with tremendous impacts on tissue regeneration, skin repair,
Th17 cell-related Multiplex immunoassays
Classically, it was known that CD4+ T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions to effect
Cancer and immune cells crosstalk: immunoediting
Immunoediting of cytokine signals provides another area of pathways which tumours utilise to evade and potentially escape from immunological targeting. This post aims at shedding some light into the Tumour
Which Histone (De)Methyltransferase modulators to choose?
Histone Methyltransferases (ex. EZH1 and EZH2, and G9a) and their counter-parts (Histone demethylases like JARID1, the KDM4, and the JMJD family) have become promising targets for inhibitor screenings,
2 assays to assess GEF and GAP activity
In my previous post Small GTPases: Measuring small G protein activation I looked at state-of the-art methods for measuring the activation of small G proteins,
Versatile measurement of protein binding to microtubules
You suspect your protein binds to microtubules? That it might stabilize or destabilize these filamentous structures? Then this post is here to help you to find a meaningful assay to validate your assumption.
How sample preparation can affect your biomarker studies (II)
In a previous post, we looked at the importance of sample preparation
Montelukast improves learning & memory in aging brain
Montelukast is a marketed drug used for asthma treatment and to relieve symptoms of seasonal allergies. It is known to function as a leukotriene receptor antagonist.