Page 6 - Scientific Library
Profiling of secretome biomarkers - pancreatic cancer
Following a post on tools for discovery of secretome biomarkers in biological samples, a recent publication by Torres et al. depicts how some of these tools (i.e. antibody arrays)
How to probe motor-domains of kinesins?
In the past, molecular motor proteins like kinesins have been investigated with macromolecular approaches. Recent research on kinesins has been focused on resolving how kinesin is regulated by intramolecular
Growth factors in cartilage biology and osteoarthritis
Cartilage is a flexible connective tissue which can rapidly grow and which is specialized to absorb and resist compression. The perichondrium, a vascularized layer, surrounds the tissue which does not
miRNA mediates gene expression through HDL particles
A recent study published in Nature Communications is the first to report how a mature microRNA (miR-223) actively controls the gene expression of a cell in which it was not originally transcribed. High
Tumour microenvironment and miRNA biomarkers
In previous posts, we have seen the role of inflammation and glycosylation
Epigenetics Writers - Readers - Erasers: Targeting Readers in Drug Discovery
DNA and Histone proteins are targets for epigenetic modifications. While DNA is only methylated, histones can be targets for diverse modifications such as methylation, acetylation, ubiquitination, phosphorylation
Glycosylation studies in the inflammasome
In a previous post on tumour microenvironment (TME) and glycosylation, we indicated that new tools for studies on glycosylation of proteins were being developed. We are happy to announce
Immunotherapy Screening - GITR:GITRL pathway
In previous blogs, I invited you to read about the relevance of the B7-1
Physioxia or Hypoxia: what it's all about
Cell culture under oxygen controlled conditions: an improvement towards more predictive results
Oxygen concentration in tissues is a key factor for cell and organ survival. In normal conditions,
Direct access to Biomarker Profiling identification tools
Profiling tools have an increasing interest for identifying new biomarkers. Different tools are available, from classical gene profiling on DNA chips, RT-qPCR arrays, Protein arrays for secretome or transcriptome,
Discovery of functional serum biomarkers
Lung cancer is one of the most common malignancies, and the leading cause of cancer-related fatality. Current diagnostic practices for common cancers rely heavily on imaging technologies. These methods