Page 9 - Scientific Library

Celastrol is a biologically active substance initially described in the traditional Chinese medicine. Celastrol (or (9ß,13α,14ß,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic

Deak AT et al. decipher the mechanisms by which mitochondria contribute to Ca2+ intracellular signaling. In their recent paper (1), they show that mitochondrial "Ca2+ buffering" close to the Endoplasmic

During my daily discussions with researchers involved in in vitro iPS and Embryonic Stem cell cultures, I am always amazed by the passion that drives them. However, the more I go in depth with them in

Successful culture of primary cells requires obtaining a maximum yield of functionally viable single cells from whole tissues. The primary factors that affect successful dissociation of whole tissue have

In Pharma screening departments there is a strong need for Ca²⁺ measurement methods.

Why is this?

GPCRs (G Protein Coupled Receptors) are still major targets of pharmaceutical screenings.

Around 30-40%

Following on from my previous post on biosimilars and biotherapeutics (or biologics), let's now take a look at some of the specific criteria for this kind of compound, which are not normally required

The U.S. Food and Drug Administration (FDA) has approved Velcade (Bortezomib) for the retreatment of adult patients with Multiple Myeloma who had previously responded to Velcade therapy and relapsed

DNA topoisomerase I and DNA topoisomerase II (Topo I and Topo II) are nuclear enzymes which regulate the topological state of the DNA helix by transiently breaking and rejoining DNA strands. They also

In a previous post on Cellular Matrices for Translational Research, I introduced HyStem hydrogels.  In order to engineer a custom culture system with HyStem, simple pilot studies or optimization

Current cancer vaccine strategies strive to efficiently deliver in situ

Cytoskeleton modeling molecules are relevant when trying to improve one's understanding of cytoskeletal molecular modeling and associated mechanisms. Together with actin binding proteins, tubulin-based

With more than 100 types of cancers affecting any part of the body, cancer is one of the leading causes of death in the world. It has an enormous impact on well-being, both for those with the diagnosis