Page 6 - Scientific Library
Cellular models to study the cardiac System (part I)
In this post, I'd like to introduce human aortic, brachiocephalic, carotid artery and coronary artery cells isolated by Cell Applications Inc. In a future post, I'll be highlighting human internal
Caspases as pharmaceutical targets - screening for inhibitors?
Caspases (cysteine-dependent aspartate-directed proteases) belong to the family of cysteine proteases and are involved in networks controlling cell death (apoptosis and necrosis) and inflammation.
Cellular models to study the Cardiac System (part II)
In a previous post, I introduced several models to study the cardiac human system. This first post introduced human aortic, brachiocephalic, carotid artery and coronary artery cells isolated by Cell Applications
Ferroptosis - and the way to inhibit it
A lot of compounds are known and available to modulate (inhibit or activate) the most prominent mode of programmed cell death - Apoptosis. In a recent post, I summarized methods to detect early Apoptosis
Differentiate between K48- and K63-specific Ubiquitination
Ubiquitination is a common post translational protein modification that occurs through an isopeptide linkage between the C-terminus of ubiquitin and the ε-amino group of a lysine residue on the target
New drug for Sickle Cell Disease targets Leukocytes
Leukocytes adhere to blood vessels as a mechanism to enter tissue where there is inflammation. Inadvertently, they pile up sickle cell red blood cells.
Mutations in the hemoglobin gene can render a person
A simple way to measure Elastin
Recently I reported about methods to measure:
- Collagen - Sircol for soluble and insoluble collagen assays
- Glycosaminoglycans - How to measure Glycosaminoglycans and Proteoglycans?
Today, I invite you to
Anti cellulite compound evaluation with in vitro adipocyte-assays
Mechanisms leading to cellulite formation is complex. It involves lipid regulatory pathways and proinflammatory cross-talk that represent promising molecular targets in cosmetology. This post introduces
9 pathway-specific screening assays in Immunotherapy
Focus on Actin - G-F Actin ratio measured in cells
In previous posts,  I invited you to look at versatile methods to
- Visualize actin: Focus on Actin staining and visualization
- Measure actin binding: Focus on Actin – Detection of actin binding and
Angiogenin favours liver cancer (HCC) growth & expansion
A publication earlier this year by Bárcena et al. shows that angiogenin plays a crucial role in the onset and development of liver cancer (hepatocellular carcinoma or HCC).
Angiogenin was the first