Scientific Library
Develop robust and convenient cell based assays with Gaussian Luciferase
Cell-based assays have become a classic way to monitor cells' reactions to a treatment or a specific stimulus. They involve a reporter construction and a detection system. The classic system is
Luciferase promoter reporter clones
Cell-based assays, screening for pathway activation or inhibition are classically done with promoter reporter clones expressing Firefly luciferase. Brighter, more stable, more sensitive, more convenient
shRNA set with improved performances
Optimal knock-down can be done by a shRNA sequence that depends on the gene expression level and the cell type. Usually, 4 shRNA should be tested to find the one inducing a minimum of 70% increase of the
ORF expressing Lentiviral system
ORF expression in Mammalian cells is very useful for many applications: protein production with HEK293, over-expression of tagged protein for immuno-tracking or immuno-precipitation, development of a cell
Gene knock-out in hard-to-transfect cells
Gene knock-out, which is gene editing leading to loss of function, just requires delivering into cells the 2 CRISPR system actors: the CAS9 endonuclease and the specific guide RNA to target
Production of eGFP mRNA Labeled with Fluorophore for Tracking of Delivery and Expression
Our Contract Research Services (CRS) team developed eGFP mRNA labeled with a fluorophore to monitor its delivery and expression efficiency in cells.
RNA Production Platform and the Associated Solutions Facilitate the Development of RNA-Based Vaccines
RNA vaccines have shown their full potential in the Covid-19 pandemic. The application of these technologies for the treatment of cancers represents a significant promise, but clinical effectiveness remains
Standardized 3D Spheroid Systems Facilitate Drug Screening and Biomarker Identification with High Relevance for Cancer Drug Discovery
Our customer needed to investigate whether modulating key culture parameters could improve the predictivity of their colorectal cancer cell-based methodology used to select
Multiplex Antibody Array for Protein Profiling and Biostatistical Analysis to Assess the Effect of Oxaliplatin on Mouse Fibrosarcoma Cell Line
Oxaliplatin (OXA) is a chemotherapeutic drug which causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin is known as immunogenic cell death
Development of Cost Effective and Robust 3D Colorectal Cancer Models for Physiological Drug Response Analysis
Our customer needed to obtain in vivo like responses to drug treatment, through monitoring parameters such as gene expression, biomarker analysis,
Lipid Nanoparticles (LNP): The New Cargo for Drug Delivery
Explore how to optimize Lipid Nanoparticules (LNP) for mRNA delivery for druf development. This study highlights key formulation parameters: buffer
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