Page 6 - Scientific Library

Analysis of Autofluorescence in Polymorphonuclear Neutrophils: A New Tool for Early Infection Diagnosis by Monsel A et al.

In a previous post I discussed 3 new unique research tools for analyzing Amyloid peptide in Alzheimer’s Disease (AD). Today, I'd like to come back to the unique properties of the Amylo-Glo® fluorescent

Bioactive small molecules facilitate numerous types of Life Science research approaches (enzyme substrates, activators and inhibitors, cell signaling modulator, cell culture...). Accessing reasonably

Cytokines and growth factors are signaling molecules that control the activities of cells through intercellular communication. Numerous families of diverse molecules are categorized as cytokines and/or

Celastrol is a biologically active substance initially described in the traditional Chinese medicine. Celastrol (or (9ß,13α,14ß,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic

Deak AT et al. decipher the mechanisms by which mitochondria contribute to Ca2+ intracellular signaling. In their recent paper (1), they show that mitochondrial "Ca2+ buffering" close to the Endoplasmic

During my daily discussions with researchers involved in in vitro iPS and Embryonic Stem cell cultures, I am always amazed by the passion that drives them. However, the more I go in depth with them in

Successful culture of primary cells requires obtaining a maximum yield of functionally viable single cells from whole tissues. The primary factors that affect successful dissociation of whole tissue have

Following on from my previous post on biosimilars and biotherapeutics (or biologics), let's now take a look at some of the specific criteria for this kind of compound, which are not normally required

The U.S. Food and Drug Administration (FDA) has approved Velcade (Bortezomib) for the retreatment of adult patients with Multiple Myeloma who had previously responded to Velcade therapy and relapsed

DNA topoisomerase I and DNA topoisomerase II (Topo I and Topo II) are nuclear enzymes which regulate the topological state of the DNA helix by transiently breaking and rejoining DNA strands. They also

In a previous post on Cellular Matrices for Translational Research, I introduced HyStem hydrogels.  In order to engineer a custom culture system with HyStem, simple pilot studies or optimization