Page 5 - Scientific Library

DNA methylation and histone post-translational modifications are key epigenetic factors.

They regulate gene expression by interfering with the chromatin structure and the binding of effector proteins

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and influence numerous cellular functions. Together with mature RNAs and small molecules, mature miRNAs can induce forced reprogramming

Proteome is referenced as the result of expression of the whole genome. With the recent developments of genomics, one could consider that this analysis is enough to decipher any biological mechanism...

In a previous post, I mentioned that the secretome is becoming a very hot topic in the world of proteome analysis, and even a crucial study subject. Today, I'd like go a step further and shed some

Following our series of posts on tumour microenvironment (TME) and the role of Cox-2/PGE2 signaling, I'd like today to focus on inflammation and immunity.

TME is a dynamic milieu influenced by numerous

Cytokines and growth factors that are produced by or have an effect on adipocytes and related peptide neuro-transmitters are central players in hunger vs. satiety balance and in eating behavior (1).

Well, in the previous posts leading up to this final one in the series, we looked at microRNA detection, overexpression, inhibition, and target detection. I'd like to finish by going over miRNA profiling.

Following a post on tools for discovery of secretome biomarkers in biological samples, a recent publication by Torres et al. depicts how some of these tools (i.e. antibody arrays) can be used to find new

A recent study published in Nature Communications is the first to report how a mature microRNA (miR-223) actively controls the gene expression of a cell in which it was not originally transcribed. High

In previous posts, we have seen the role of inflammation and glycosylation in the tumour microenvironment (TME). All these are mainly factors at the protein level causing the tumour cells to evade the

In a previous post on tumour microenvironment (TME) and glycosylation, we indicated that new tools for studies on glycosylation of proteins were being developed. We are happy to announce that they are