Page 4 - Scientific Library
mTOR revisited
The PI3K/Akt/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. It is directly related to cellular quiescence, proliferation,
IL-1 family quantified simultaneously...at last!
The IL-1 family has long been known as a key player in the effector role of macrophages in innate defence against tumours and infections. It plays an important role in the field of natural / innate immunity
Vive la différence! To pool or not to pool...
In a previous post on whether samples should be pooled or not for proteomic profiling, we discussed this approach, which can be quite cost-wise, while still allowing to see the main biomarkers
New Glycan Array - Sweet 17? Sweet 100!
Glycocalyx, literally meaning 'sugar coat', is an extracellular polymeric coating surrounding many prokaryotic and eukaryotic cells that consists of glycoproteins, glycolipids, proteoglycans and glycosaminoglycans.
Discovery of new biomarkers... 3 tips regarding controls
One of the recurrent questions that we get at the Biomarkers team at tebu-bio is on what controls should be included in a given experiment. Either if the experiment is done by researchers in their lab,
How sample preparation can affect your biomarker studies (I)
In previous posts, we have discussed about whether samples should be pooled, how much (and if) they should be diluted, and how biologicals can affect the
Oxygen and miRNAs in Cosmetology and Dermatology
A recent review by Nadim et al. casts some light on a Cosmetology and Dermatology, where circulating biomarkers, though studied to a certain extent so far, are yet unknown for many skin models.
Monoclonal antibodies validated for PTM studies
Knowing the Human genome better has allowed major advancements in Personalised Medicine. Nowadays, we can know (if we want) the likelihood to develop a given disease and/or how we will react to different
58 different human RTKs in one phosphorylation array
The Receptor Tyrosine Kinases (RTKs) are an important family of cell-surface receptors transmitting extracellular stimuli (ex. NGF, PDGF, FGF, EGF, Insulin...)
See how researchers get good quality publications with arrays
New findings in the TGF-beta pathway
Three papers on the role of the TGF-beta pathway in different cancers have recently been published.
It was already known that this pathway is involved in processes such as cell growth,