Mouse anti-CD11b, clone EBS-CD-010 (Monoclonal) - 100 ug

Integrin αM (also designated complement component receptor 3 α-chain; CD11b (p170); macrophage antigen α polypeptide; cell surface glycoprotein Mac-1 α-subunit; CR3 α-chain; MAC1A; MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an α-chain and a β-chain. Integrin αM combines with Integrin β2 (CD18) to form a leukocyte-specific integrin referred to as macrophage receptor-1 (Mac-1) or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin αM-β2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.