Mouse anti-CD11a, clone CRIS-3 (Monoclonal) - 100 ug

Cris-3 reacts with CD11a, a transmembrane molecule with 1145 amino acid residues and a MW of 180 kDa. CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages. Levels on memory T-cells ten to increase. CD11a plays a key role in mediating leukocyte adhesion to endothelium during inflammatory responses through binding to ICAM-1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many other T-cell functions and immune phenomena. When paired with CD18, it forms the integrin alphaLbeta2 heterodimer also called LFA-1. LFA-1 is chiefly responsible for lymphocyte adhesion.