d5-D-myo-Phosphatidylinositol 3 4 5-trisphosphate DiC16 - 1 mg

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from dysregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2. This analog is deuterated at the glycerol.