Scientific Library
PGE2 role in carcinoma chemoresistance via CSC repopulation
The involvement of Prostaglandin E2 (PGE2) in cancer development has already been described (see the post "Tumour microenvironment – the dark side of PGE2). Recently, Kurtova et al. confirmed this
20S Proteasome inhibitors and Leptin against obesity
The World Health Organization (WHO) estimated in 2008 that 1.4 billion adults worldwide were overweight and of these 500 million were obese with risks for developing type 2 diabetes, hypertension and cardio-vascular
O-Glucuronide synthesis made easy
6 popular Microtubule agents used in in vitro tubulin assays
Microtubules are key components of the cytoskeletal structure of eukaryotic cells. Composed of alpha- and beta- tubulin sub-units, microtubules are dynamic entities
Neuromuscular diseases: A new application for Statins?
Statins are HMG-CoA reductase inhibitors, well-known  medications for treating Hypercholesterolemia. Simvastatin is a member of this "Statin family" and controls
3D Cell culture: Innovative cell culture devices for more predictive 3D models
One of the biggest challenges as a researcher in life sciences, is to obtain proof of concept the more predictive as possible. To help you to reach your objectives, many innovative tools are being developed
3D cell culture Biochip - versatile for more physiological applications
By mimicking in-vivo environments, 3D cell culture models appear nowadays as the best in-vitro study model to work in an in-vivo like study model and to obtain more physiologically relevant data and proof
AIM Biochips - 3D cell culture platform for Immunotherapy and T Cell therapy studies
As mentioned in a previous post the DAX Biochips from AIM Biotech are an innovative and versatile microfluidic platform, allowing researchers to more easily develop 3D cell culture models, to work as close
STING: key player in drug development?
Recent articles have highlighted the role the STING cell signalling pathway may be playing in drug development, whether via its inhibition to control innate immunity and inflammation (Nature Biotechnology,
Immunotherapy for breast cancer: Types and effectiveness
Our body is made up of trillions of cells grouped together to form tissues and organs. The genes present in the nucleus of every cell tell it when to grow, work, divide and die.
Normally, our cells follow
CRO & Drug Discovery
In medicine, biotech and pharmacology, drug discovery is the entire process to discover new candidate medications.
The process is long and complex, the budget needed is expansive and the skills required