Mitochondria keep cells "healthy" in their environment. In this post, we'll take a look at a new fluorescent assay for the monitoring of mitophagy, a process aimed at clearing damaged or superfluous mitochondria

Research tools aimed at exploring mitochondria are becoming more and more popular and cover multiple experimental applications. They go from primary antibodies validated for immuno-assays (see "

In the field of Drug Development, 3D cell culture models such as spheroids or organoids currently appear as one of the best solutions to obtain accurate and physiological in vitro

Due to its involvement in many cellular processes such as normal ageing, tumor suppression, chronic diseases and many more, cellular senescence has gained increasing attention since its first description

Cell-Based ELISA tests now enable precise measurement of the phosphorylation status or expression profiles of target proteins (biomarkers) in whole cells. In this post, a review of high performing cell-based assays is made.

Interestingly, the experimental design is simple and is based on 3 steps:

1. Plate
2. Treat and fix your cells of interest (adherent or in suspension)
3. Detect the target proteins with the optimized reagents provided in the kit (450 nm colorimetric detection)

These Colorimetric Cell-Based ELISA Kits enable the detection of various target proteins (biomarkers). Some references also enable the precise measurement of the phosphorylation status of proteins of interest. They can easily

Involved in many physiological processes (apoptosis, aging, cell signalling..) and numerous diseases (cardiovascular disorders, to cancer and neuro-degenerative diseases…), Mitochondria have become more

All human and living beings have mitochondria. These are tiny cellular organisms present in nearly every cell of an individual. They are located more precisely inside the cells, in their nucleus. The main

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

In their latest publication in Nature, Dr. Moiseeva et.al., studied cellular senescence in skeletal

Mitochondrial Dynamics and Mitochondria-Lysosome Contacts in Neurogenetic Diseases

In an article published in frontiers in Neuroscience, with the aim to study cellular phenotypes

Understanding cellular senescence and oxygen consumption rate

A recent paper published in Science reported a 50% reduction in mortality and improved immune response in old mice infected

Relationship between antitumor effects and active oxygen

ROS (Reactive oxygen species) are highly reactive oxygen species mainly generated during the ATP synthesis process in mitochondria.