Scientific Library
CBR-5884 - a Serine biosynthesis inhibitor for cancer research
Metabolic pathways are upregulated in cancer cells to promote their growth and proliferation. The evidence pointing to the requirement of the amino acid serine in tumorigenesis is overwhelming. Serine
How to activate or inhibit autophagy?
The term Autophagy was introduced by Christian de Duve during the Ciba Foundation Symposium on Lysosomes – which was held in London in February 1963. In 1974 he was honoured with the Nobel price in
Stauprimide inhibits c-myc transcription in cancer cells
Stauprimide is known to prime Embryonic Stem Cells (ESC) by targeting the c-Myc-activating transcription factor NME2. Its mechanism of action is linked to the inhibition of the nuclear localization of
Bioactive neuronal lipid mediators: a focus on Synaptamide
Focus Biomolecules produces a broad range of bioactive lipid mediators as well as many small molecule inhibitors of numerous lipid metabolic pathways for use as cellular probes. These can be supplied
GPR17 and Remyelination: activators and antagonists
The absence of mature oligodendrocytes for the repair of demyelination lesions is a critical factor in the pathology of Multiple Sclerosis (MS), and other debilitating CNS disorders of myelination. As
Production of eGFP mRNA Labeled with Fluorophore for Tracking of Delivery and Expression
Our Contract Research Services (CRS) team developed eGFP mRNA labeled with a fluorophore to monitor its delivery and expression efficiency in cells.
RNA Production Platform and the Associated Solutions Facilitate the Development of RNA-Based Vaccines
RNA vaccines have shown their full potential in the Covid-19 pandemic. The application of these technologies for the treatment of cancers represents a significant promise, but clinical effectiveness remains
Standardized 3D Spheroid Systems Facilitate Drug Screening and Biomarker Identification with High Relevance for Cancer Drug Discovery
Our customer needed to investigate whether modulating key culture parameters could improve the predictivity of their colorectal cancer cell-based methodology used to select CDK8 inhibitors and/or identify
Multiplex Antibody Array for Protein Profiling and Biostatistical Analysis to Assess the Effect of Oxaliplatin on Mouse Fibrosarcoma Cell Line
Oxaliplatin (OXA) is a chemotherapeutic drug which causes DNA cross-linking damage, preventing DNA replication and transcription and leading to cell death. Oxaliplatin is known as immunogenic cell death
Development of Cost Effective and Robust 3D Colorectal Cancer Models for Physiological Drug Response Analysis
Our customer needed to obtain in vivo like responses to drug treatment, through monitoring parameters such as gene expression, biomarker analysis, cellular viability, invasion capability.
Lipid Nanoparticles (LNP): The New Cargo for Drug Delivery
Explore how to optimize Lipid Nanoparticules (LNP) for mRNA delivery for druf development. This study highlights key formulation parameters: buffer composition, lipid selection; crucial for enhancing transfection
Unlock the Full Potential of Your Protein Production
Flexible Protein Production Services for Custom Expression & Purification
Tebubio’s Protein Production Platform offers custom expression strategies using bacterial & mammalian (HEK293) systems. Our adaptable