Scientific Library
How to monitor mitophagy in mammalian cells
Mitochondria keep cells "healthy" in their environment. In this post, we'll take a look at a new fluorescent assay for the monitoring of mitophagy, a process aimed at clearing damaged or superfluous mitochondria
Cell-based assays with hPBMCs for cell therapy and drug discovery
Human Peripheral Blood Mononuclear Cells (hPBMCs) are essential for designing cellular models to be used in cell therapy and drug discovery research programs [1-7, 12]. Being able to access reliable and
How to easily visualize and quantify cellular senescence
Due to its involvement in many cellular processes such as normal ageing, tumor suppression, chronic diseases and many more, cellular senescence has gained increasing attention since its first description
MitoTools: Mitochondrial research has never been so easy
Involved in many physiological processes (apoptosis, aging, cell signalling..) and numerous diseases (cardiovascular disorders, to cancer and neuro-degenerative diseases…), Mitochondria have become more
What mitochondria related diseases?
All human and living beings have mitochondria. These are tiny cellular organisms present in nearly every cell of an individual. They are located more precisely inside the cells, in their nucleus. The main
Senescent cells prevent muscle regeneration
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
In their latest publication in Nature, Dr. Moiseeva et.al., studied cellular senescence in skeletal
Mitochondria-Lysosome Contacts in Neurogenetic Diseases
Mitochondrial Dynamics and Mitochondria-Lysosome Contacts in Neurogenetic Diseases
In an article published in frontiers in Neuroscience, with the aim to study cellular phenotypes
Understanding cellular senescence and oxygen consumption rate
Understanding cellular senescence and oxygen consumption rate
A recent paper published in Science reported a 50% reduction in mortality and improved immune response in old mice infected
Relationship between antitumor effects and active oxygen
Relationship between antitumor effects and active oxygen
ROS (Reactive oxygen species) are highly reactive oxygen species mainly generated during the ATP synthesis process in mitochondria.
Alzheimer’s Amyloid-β Accelerates Cell Senescence and Suppresses SIRT1 in Human Neural Stem Cells
In this blog, discover three assay kits developed by our partner Dojindo to accurately quantify and detect SA-β-Gal activity, and to explore a broad range of cellular processes linked to senescence.