Page 2 - Scientific Library

In Pharma screening departments there is a strong need for Ca²⁺ measurement methods.

Why is this?

GPCRs (G Protein Coupled Receptors) are still major targets of pharmaceutical screenings.

Around 30-40%

DNA topoisomerase I and DNA topoisomerase II (Topo I and Topo II) are nuclear enzymes which regulate the topological state of the DNA helix by transiently breaking and rejoining DNA strands. They also

Cytoskeleton modeling molecules are relevant when trying to improve one's understanding of cytoskeletal molecular modeling and associated mechanisms. Together with actin binding proteins, tubulin-based

With more than 100 types of cancers affecting any part of the body, cancer is one of the leading causes of death in the world. It has an enormous impact on well-being, both for those with the diagnosis

The Transient Receptor Potential (TRP) ion channel family participates in numerous functions of the Nervous System. A recent publication tends to indicate that TRP might also be of interest for therapeutical

Kv1.3 channels are expressed in T-cell lymphocytes and over-expressed in autoimmune diseases. They can be see as a therapeutic taget for T cell mediated autoimmune diseases.

ShK toxin (Stichodactyla helianthus

Many recombinant proteins (rec. proteins) are now commercially available. And many of them, mainly secreted soluble proteins, are biologically active, so there shouldn't be any need to look for alternatives

The term Autophagy was introduced by Christian de Duve during the Ciba Foundation Symposium on Lysosomes - which was held in London in February 1963. In 1974 he was honoured with the Nobel price in

A lot of compounds are known and available to modulate (inhibit or activate) the most prominent mode of programmed cell death - Apoptosis. In a recent post, I summarized methods to detect early Apoptosis

Cell death can be caused by external factors such as infection or trauma - a process which is call necrosis. On the other hand, cell death can be mediated by intracellular programs - in this cases we talk

Epothilone B is a bioactive microtubule-stabilizing small molecule. This blood-brain barrier permeable coumpound belongs to the most popular potent cytoskeletal modeling molecules for in vitro cell based

Originally identified as an active molecule against the Borrelia species, Borrelidin has since been described as a selective inhibitor of threonyl tRNA synthetase (ThrRS). More recent research has