Page 5 - Scientific Library
How can TR-FRET facilitate your cell signalling studies?
Time-Resolved Förster Resonance Energy Transfer (TR-FRET) is a robust and homogeneous fluorescence detection technology and a real alternative to ELISA to perform Cell Signalling studies. Based on this
New Primary cell Models: a focus on Kidney cells
tebu-bio is pleased to announce their new partnership for a European distribution of Novabiosis, a US based manufacturer providing cryopreserved primary human cells for the biotechnology, pharmaceutical
World's first 3',3'-Cyclic CAMP ELISA
The cGAS-cGAMP-STING cell signalling pathway plays a critical role in antiviral and antitumor immunity as well as mediating autoimmune responses. Dysregulation or aberrant activation of the pathway by
New SARS-CoV/ACE2 inhibitor assays & small molecules for drug discovery
Many initiatives led by worldwide scientific networks are currently being launched to decipher cellular mechanisms involved in SARS-CoV-2 cellular entry. For example, a recent study has identified 332
How to monitor inflammatory cytokines in anti-COVID drug discovery
The close relation between Severe Acute Respiratory Syndrome (SARS), unpaired adaptive immune responses and overexpression of inflammatory cytokines has been described more than a decade ago (1, 2).
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How are mRNA vaccines changing drug discovery?
mRNA vaccines are developing very quickly with dozens of ongoing clinical trials against cancers or infectious diseases (e.g. HIV or more recently SARS-Cov-2). Recombinant monoclonal antibody (mAB) based
COVID-19: relevant cell culture models
One of the challenges in respiratory research in general, and for COVID-19 related projects in particular, is to have access to relevant in vitro cell culture models. Human lung epithelium models are currently
Immuno-Oncology: 6 must-haves to boost your projects
Alone, or in combination with other therapies, Immuno-Oncology (I-O) appears currently as one of the most promising research fields to fight cancer. Nevertheless, developing breakthrough therapies to fully
Reprogramming stem cells: a new innovative technology for the development of consistent and functional human cells
To overcome current cell model limitations, bit.bio have developed a new, innovative technology to reprogram human stem cells with precise control of transcription factor expression through iPSC engineering.
Consistent, scalable human iPSC-derived glutamatergic neurons and skeletal myocytes
As detailed in a separate post, bit.bio have developed a novel cellular reprogramming technology, opti-ox™1 (optimized inducible overexpression), that can generate functional cells with high consistency
How can you get your mRNA ready in only a few weeks?
Synthetic mRNA is indeed the highway for today's therapeutics, whether you're working on developing new drugs against cancer targets, or whether you aim to develop new vaccines, Covid-19 being one of them.