The cGAS-cGAMP-STING cell signalling pathway plays a critical role in antiviral and antitumor immunity as well as mediating autoimmune responses. Dysregulation or aberrant activation of the pathway by

The close relation between Severe Acute Respiratory Syndrome (SARS), unpaired adaptive immune responses and overexpression of inflammatory cytokines has been described more than a decade ago (1, 2).
More

mRNA vaccines are developing very quickly with dozens of ongoing clinical trials against cancers or infectious diseases (e.g. HIV or more recently SARS-Cov-2). Recombinant monoclonal antibody (mAB) based

Alone, or in combination with other therapies, Immuno-Oncology (I-O) appears currently as one of the most promising research fields to fight cancer. Nevertheless, developing breakthrough therapies to fully

Following on from the popular SiR-Probes, earlier this year Spirochrome introduced new SPY probes, as presented in this post.

Take a few minues to watch this video of the SPY™ Actin, Tubulin and DNA

Synthetic mRNA is indeed the highway for today's therapeutics, whether you're working on developing new drugs against cancer targets, or whether you aim to develop new vaccines, Covid-19 being one of them.

Despite its importance in the regulation of many cellular processes, membrane tension is still complicated to measure. And despite valuable insights, the techniques currently available remain complex and

With the great success of the SIR-probes for efficient labeling of the cell Cytoskeleton, DNA and Lysosome, Spirochrome have just launched a series of 10 new live cell fluorescent tools : The SPY^TM probes

Protocole de Western Blot (WB) - Recommandé par les utilisateurs d'anticorps Tebubio

Protocole WB & conseils techniques - améliorez la reproductibilité de vos résultats

Forts de leur propre expérience

Tips and tricks to design and test qPCR primers - advanced procedure

Design and test your own qPCR primers

1. Find the NCBI Gene page for the gene you would like to study. For example, for Human GAPDH.
2. Scroll

Amino acids are organic compounds that combine to form proteins of every living matter. Amino acids are used by the organism for building blocks of proteins.

When proteins are digested or broken down,

An antibody is a molecule produced by the organism to detect and neutralise specific pathogens. Antibodies are the defence proteins that our immune system produces when it is exposed to an infectious microorganism