Page 11 - Scientific Library
PBMCs & drug development
Use of human samples including peripheral blood mononuclear cells (PBMCs)Â in drug discovery is critical for increasing the chances of success for a small molecule screen hit. A review based on recent
HD-LCI video of HUVEC Transfection with Cytofect Kit
See human cells glow with green fluorescent protein in this time-lapse video. These images were captured over 20 hours via Lumascope 620.
[youtube https://www.youtube.com/watch?v=k5esUe_rrr4]
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High Definition
Hepatic Cellular Models
A wide range of in vitro models are used in preclinical drug testing for the investigation of ADME-Tox (Absorption, Distribution, Metabolism, Excretion and oxicity) properties of New Chemical Entities
Cellular models for studying the human urogenital system
The urogenital system is the organ system of the reproductive organs and the urinary system. These are grouped together because of their proximity to each other, their common embryological origin and the
How to manipulate and measure Autophagy?
The term Autophagy was introduced by Christian de Duve during the Ciba Foundation Symposium on Lysosomes - which was held in London in February 1963. In 1974 he was honoured with the Nobel price in
Cellular models to study the cardiac System (part I)
In this post, I'd like to introduce human aortic, brachiocephalic, carotid artery and coronary artery cells isolated by Cell Applications Inc. In a future post, I'll be highlighting human internal
Cellular models to study the Cardiac System (part II)
In a previous post, I introduced several models to study the cardiac human system. This first post introduced human aortic, brachiocephalic, carotid artery and coronary artery cells isolated by Cell Applications
Differentiate between Apoptosis, Necroptosis, Autophagy & Ferroptosis
Cell death can be caused by external factors such as infection or trauma - a process which is call necrosis. On the other hand, cell death can be mediated by intracellular programs - in this cases we talk
Live cell imaging in action: Killer T-cells hunt their target
In a recent video posted on "Cambridge University's YouTube channel", Professor Gillian Griffiths and co-workers prove how the Life Science Community can benefit from modern and innovative cellÂ
Modulating or inhibiting Caspase activities
In a previous post, I discussed Caspases as pharmaceutical targets - how to screen for inhibitors?
Today I would like to concentrate on Caspase inhibitors/modulators, which allow for in-depth characterisation
3D monitoring of cell movement through Collagen I
The transition from non-invasive phenotype to invasive phenotype of tumor cells marks the switch from a benign tumor to a more malignant form of cancer. Understanding the mechanisms underlying this hallmark
Neuroregenerative effects of microtubule stabilizing Epothilone B
Epothilone B is a bioactive microtubule-stabilizing small molecule. This blood-brain barrier permeable coumpound belongs to the most popular potent cytoskeletal modeling molecules for in vitro cell based