Page 3 - Scientific Library

There is an increasing demand for new cholesterol-lowering therapies in addition to existing treatments (e.g. targeting statins). The pharmacological inhibition of PCSK9-mediated LDLR degradation

Autotaxin (ATX) is a secreted lysophospholipase D involved in the release of the lipid mediator LPA. Many research tools have been developed to study ATX-LPA signaling.  In this post, I invite you

Extracellular adenosine 5'-triphosphate (ATP) is released by dying and damaged cells, and it acts on many immune cells to promote

ADCC is a simple but important mechanism for the immune system to target diseased or infected cells. Antibodies bind to specific antigens on

Immunotherapy represents a field in Drug Discovery which is quickly developing and leading to significant progress in treatments of a number of diseases, especially cancer. The approach is based on inducing,

Today, I'd like to give you an overview about methods in actin research with validated R&D products and kits which will allow you to measure binding to actin and effects on the polymerisation dynamics

PD-1 / NFAT Reporter - Jurkat Cell Line

The PD-1 reporter cell line is

Progesterone derived Allopregnanolone (ALLO) is an extensively studied neurosteroid that has been shown to be involved in neurodegenerative diseases, including Alzheimer's, Parkinson's disease, and multiple

As a regulator of the immune system, Immune checkpoints appear to be privileged targets In Drug Discovery and Immunotherapy

Over the last several years, the Immune System has appeared as a central, priority target to fight cancer and various other diseases. Currently, in cancer

Due to its involvement in many cellular processes such as normal ageing, tumor suppression, chronic diseases and many more, cellular senescence has gained increasing attention since its first description