4-Dedimethylaminosancycline (CMT-3) - 10 mg

Chemically modified tetracyclines show activity in mammalian cell pathways and diseases related to cancer inflammation and neurodegenerative pathways. 4-Dedimethylaminosancycline (CMT-3 or COL-3) acts as matrix metalloproteinase (MT-MMP) inhibitor. It has been studied in disorders of collagen destruction excessive TNF activity excessive nitric oxide activity excessive IL-1 activity excessiuve activity of elastase bone loss protein degradation muscle wasting collagen glycosylation phospholipase A2 activity. In addition CMT-3 has been investigated for the treatment of aneurysms ulcerations periodontal disease diabetes scleroderma progeria cancer and diseases of bone marrow function and thrombocytopenia.Alternate names: CMT-3 COL-3 COL-3 Compound Incyclinide NSC-683551