XL413·HCl - 5 mg

Activity: Cdc7 inhibitor/CRISPR enhancer . Function/Pharmacology: XL413 is a potent (IC50 = 4.8 nM) ATP-competitive inhibitor of the important DNA replication initiation kinase Cdc7 (DDK).1 It increases the efficiency of homology directed DNA repair in CRISPR-Cas9 gene editing.2 XL413 acted synergistically with other chemotherapy agents in various cancer models.3-5 Chemical Name: 8-Chloro-2-[(2S)-pyrrolidin-2-yl]-3H-[1]benzofuro[3,2-d]pyrimidin-4-one hydrochloride