SPY595-DNA is a bright, photostable, red & non toxic live cell nuclear stain based on SPY™ dyes series. Its optimized structure allows quick labeling of DNA in live & fixed cells with high specificity and very low background. SPY595-DNA stains the nuclei of live or fixed cells without the need for genetic manipulation or overexpression of fluorescent proteins. Its emission in the red minimizes phototoxicity and sample autofluorescence. SPY595-DNA enables multicolor imaging with SPY505, SPY555, SPY650, SPY700, SiR and GFP. SPY595-DNA can be imaged with standard Alexa594™ or Texas Red filtersets. It can be used for widefield, confocal, SIM or STED imaging in living or fixed cells and tissue.