Mouse anti-CD8a, clone RIV11 (Monoclonal) - 100 ug

RIV11 recognizes a protein of 32 kDa, identified as CD8a. The CD8 molecule consists of α and β chains, which are disulphide-linked into heterodimers or homodimers. CD8 is expressed on a T-cell subset (cytotoxic/suppressor T-cells), thymocytes and NK-cells. The majority of CD8+ T-cells express CD8 as heterodimer. Some subpopulations of CD8+ T-cells as well NK-cells may express homodimer. CD8 functions as a co-receptor in concert with TCR for binding the MHC class I/peptide complex. HIV-2 envelope glycoprotein binds CD8 α chain but not CD8 β chain.