KRAS(G12D) Nucleotide Exchange Assay Kit - 384 rxns.

It is well established that RAS mutations are responsible more than 30% of human cancers. KRAS(G12D) is one of the KRAS mutations that is found frequently in pancreatic and colon cancers. Recent studies have led to the discovery of a small molecule called MRTX-1133 that locks KRAS conformation in the GDP-bound state, thereby blocking KRAS(G12D)-mediated signaling pathway. Compounds that affect the nucleotide exchange (GDP to GTP) reaction in KRAS could lead to a novel approach to the inhibition of tumor cell growth in KRAS(G12D)-driven tumors.