(+)-JQ-1-PEG4-Amido-N-t-Boc - 100 MG

(+)-JQ-1-PEG4-Amido-N-t-Boc possesses a Boc-protected amino (NH2) group, which is reactive with activated NHS esters or carboxylic acid in the presence of EDC or HATU, and (+)-JQ-1, which functions as a potent, specific, and reversible pan-BET (bromodomain and extra-terminal motif) family inhibitor. t-Boc-aminooxy can be deprotected under mild acidic conditions. (+)-JQ-1 can be a useful chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis. The PEG4 spacer bolsters hydrophilicity.