Isohelenin - 5 mg

Activity: NFkB inhibitor . Function/Pharmacology: A sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFB (complete inhibition at 5 M)1 acting via inhibition of IKK6. Isohelenin-mediated NFB inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6 Chemical Name: (3aR,8aR,9aR)-8a-methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one