Mitochondria

Unlocking Mitochondrial Function: Small Molecules Targeting Core Cellular Pathways

 

Last month, we introduced Mitochondria related compounds offered by our partners Focus Biomolecules and TargetMol to you tackling the following subjects: Glutathion, Oxidative Phosphorylation/Respiratory Chain, ROS and a number of Targeted Reagents.

 

 

In "Part 2" of this mitochondrial focus, we turn our attention to three key areas:

These processes are central to mitochondrial performance, and critically, can be modulated by small molecules and compounds. This makes them powerful entry points for exploring mitochondrial function and dysfunction.

Understanding these mechanisms is increasingly vital, as mitochondrial dysregulation is now recognized as a driving force behind a wide range of conditions, including metabolic disorders, neurodegenerative diseases, ischemic heart and brain injury, cancer, cardiovascular disease, and aging.

Krebs Cycle Related Compounds

  • Copper chelator/Cuproptosis inducer
  • CAS: 488832-69-5
  • Fumarate hydratase inhibitor
  • CAS: 1644060-37-6
  • Isocitrate dehydrogenase 1/2 inhibitor
  • CAS:  1644545-52-7

Molecules Related to Mitochondrial Transporters

  • Inhibits MPT pore opening
  • CAS: 11076-19-0
  • MPTP inhibitor
  • CAS: 75450-34-9
  • NCX inhibitor
  • CAS: 182004-65-5
  • Inhibits Cancer Cell Metabolism
  • CAS: 50264-69-2
  • Mitochondrial import inhibitor
  • CAS: 303215-67-0
  • TIMM44 blocker
  • CAS: 394694-98-5
  • Mitochondrial import inhibitor
  • CAS: 522-51-0
  • Mitochondrial ATPase inhibitor
  • CAS: 579-13-5
  • Endogenous Uncoupler of Mitochondrial Respiration
  • CAS: 136560-78-6

     

  • Translation inhibitor
  • CAS: 58-58-2
  • Mitochondrial pyruvate transporter inhibitor
  • CAS: 56396-35-1

Molecules Related to Membrane Permeability

  • Pore-forming antimicrobial peptide
  • CAS: 27061-78-5
  • IKK inhibitor
  • CAS: 34031-32-8
  • Disrupts mitochondrial volume
  • CAS: 26048-05-5
  • Induces mitochondrial permeability pore opening
  • CAS: 472-15-1
  • Inhibits MPT pore opening
  • CAS: 11076-19-0
  • Mitochondrial toxin
  • CAS: 157232-64-9
  • Inhibitor of CTP: choline-phosphate cytidylyltransferase
  • CAS: 166981-13-1 (free base)
  • Inhibits mitochondrial permeability pore opening
  • CAS: 59865-13-3
  • MPTP inhibitor
  • CAS: 55486-00-5
  • Inhibits mitochondrial oxidative phosphorylation
  • CAS: 370-86-5
  • Mitochondrial division inhibitor
  • CAS: 338967-87-6
  • Monovalent cation ionophore K+ and NH4+
  • CAS: 6833-84-7
  • Cancer stem cell inhibitor
  • CAS: 55721-31-8
  • Neurotrophic agent
  • CAS: 22033-87-0
  • Cytotoxic disulfide antibiotic
  • CAS: 750590-18-2
  • Induces loss of mitochondrial membrane potential
  • CAS: 2001-95-8

  • References


    Article content created by Tebubio using courtesy materials provided by Focus Biomolecules and TargetMol.

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