Mitochondria

Explore Small Molecules Targeting Mitochondrial Metabolism, ROS Regulation, and Oxidative Phosphorylation

Mitochondrial dysfunction plays a central role in metabolic disorders, neurodegenerative diseases, cardiovascular disease, ischemic injury, cancer, and aging.

As key regulators of cellular energy production, apoptosis, calcium signaling, and metabolic homeostasis, mitochondria are a critical research focus across therapeutic areas.

In Part 1 of our mitochondrial compound focus, we present a curated selection of research tools from Focus Biomolecules and TargetMol, covering:

Part 2 (next month) will explore Krebs cycle, mitochondrial transporters, and membrane permeability.

Glutathione & Redox Modulators

Compounds impacting cellular antioxidant systems and redox balance

  • Glutathione/thioredoxin reductase inhibitor
  • CAS: 1133387-90-2
  • Glutathione sponge
  • CAS: 1080-12-2
  • Inhibits NFkB activation
  • CAS: 104594-70-9
  • Antioxidant
  • CAS:  3650-09-7
  • Glutathione sponge / Increases ROS levels
  • CAS: 20069-09-4

Oxidative Phosphorylation & Respiratory Chain

Tools targeting mitochondrial complexes and bioenergetics

  • 23187: Ca2+ ionophore
  • CAS: 52665--69-7
  • Mitochondrial Complex III inhibitor
  • CAS: 1397-94-0
  • Kills cancer stem cells / Depolarizes mitochondria
  • CAS: 88495-63-0
  • Mitochondrial cytochrome bc1 complex inhibitor
  • CAS: 26166-39-2
  • Mitochondrial protonophore uncoupler
  • CAS: 210302-17-3
  • HIF-1 / Mitochondrial complex I inhibitor
  • CAS: 1227158-85-1
  • Disrupts mitochondrial volume
  • CAS: 26048-05-5
  • JSP-1 phosphatase inhibitor
  • CAS: 101439-76-3
  • Mitochondrial toxin
  • CAS: 157232-64-9
  • Mitochondrial and Ectopic ATPase inhibitor
  • CAS: 25425-12-1
  • Mitochondria-targeted reagent
  • CAS: 15510-55-1
  • Mitochondrial function enhancer
  • CAS: 536-43-6
  • Inhibits mitochondrial oxidative phosphorylation
  • CAS: 370-86-5
  • NADH oxidase inhibitor
  • CAS: 341-88-8
  • Mitochondrial Complex I Inhibitor
  • CAS: 1570496-34-2
  • Cytochrome bc1 reductase inhibitor
  • CAS: 12689-26-8
  • AMPK activator/Mitochondrial protein complex I inhibitor
  • CAS: 1422365-93-2
  • Inhibitor of lysine demethylase PHF8 
  • CAS: 1574530-99-6
  • NCX inhibitor
  • CAS: 182004-65-5
  • Mitochondria specific, photo-activated protonophore
  • Endogenous Uncoupler of Mitochondrial Respiration
  • CAS: 136560-78-6
  • Induces rapid intracellular acidification
  • CAS: 28643-80-3
  • Mitochondrial ATPase inhibitor
  • CAS: 1404-19-9
  • Autophagy inducer / Anticancer
  • CAS: 4611-05-6 
  • S6K1 inhibitor
  • CAS: 125517-76-0
  • Mitochondrial complex I inhibitor
  • CAS: 2738-64-9
  • mtDNA activator
  • CAS: 3068830-89-4
  • NFkB inhibitor / Store operated calcium entry
  • CAS: 545380-34-5
  • Mitochondrial Complex I Inhibitor
  • CAS: 83-79-4
  • Mitochondrial Complex II inhibitor
  • CAS: 326-91-0
  • PDGFR kinase inhibitor and Oxidative phosphorylation inhibitor
  • CAS: 10537-47-0
  • Mitochondrial pyruvate transporter inhibitor
  • CAS: 56396-35-1

ROS-Related Molecules

Molecules regulating mitochondrial oxidative stress

  • Carnitine palmitoyltransferase inhibitor
  • CAS: 828934-41-4
  • Antioxidant
  • CAS: 10309-37-2
  • Cellular protectant
  • CAS: 66611-37-8
  • SIRT3 activator
  • CAS: 35354-74-6
  • Mitochondrial Complex I Inhibitor
  • CAS: 1570496-34-2
  • Inhibitor of lysine demethylase PHF8
  • CAS: 1574530-99-6 
  • Mitochondria targeted antioxidant
  • CAS: 1334850-99-5
  • Mitochondria-targeted antioxidant
  • CAS: 444890-41-9
  • Mitochondria-targeted antioxidant
  • CAS: 845959-50-4
  • Mitochondrial Complex II inhibitor
  • CAS: 326-91-0
  • Mitochondria-targeted antioxidant
  • CAS: 934826-68-3

Mitochondria-Targeted Reagents

Specialized tools for mitochondrial targeting and functional assays

  • Mitochondrial-targeted hydrogen sulfide donor
  • CAS: 1429173-57-8
  • KGDH and PDH inhibitor
  • CAS: 95809-78-2
  • Mitochondria-targeted reagent 
  • CAS: 15510-55-1

  • TRAP1 Inhibitor
  • CAS:  1620160-42-0

  • Mitochondrial GPDH inhibitor
  • CAS: 27031-00-1

  • Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
  • CAS: 2304621-31-4

  • Mitochondrial DNA transcription inhibitor/RNA Polymerase inhibitor
  • CAS: 2304621-06-3

  • Mitochondrial membrane potential probe
  • CAS: 3520-43-2
  • Mitochondria-targeted antiglycolytic agent
  • CAS: 2361564-49-8
  • Mitochondria specific, photo-activated protonophore
  • Mitochondria targeted antioxidant
  • CAS: 1334850-99-5

  • Mitochondria-targeted antioxidant
  • CAS: 444890-41-9

  • Mitochondria-targeted antioxidant
  • CAS: 845959-50-4 (parent MitoQ)
  • Mitochondria-targeted antioxidant
  • CAS: 845959-50-4
  • mtDNA activator
  • CAS: 3068830-89-4
  • Mitochondria-targeted antioxidant
  • CAS:  934826-68-3

  • References


    Article content created by Tebubio using courtesy materials provided by Focus Biomolecules and TargetMol.

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