Now Available: TriLink's New CleanCap® IVT Kits for Fast, High-Yield mRNA Synthesis

New CleanCap® AG (3′ OMe) CleanScript™ IVT Kit now available:

Discover the new CleanCap® AG (3′ OMe) CleanScript™ IVT Kit from TriLink, now available at Tebubio.

Achieve high-yield, low-dsRNA mRNA synthesis in a single reaction, powered by CleanCap® technology and backed by our expert European support.

A Simpler, More Powerful Way to Synthesize Capped mRNA

Researchers working in mRNA therapeutics and vaccines know the pressure: deliver high-quality, high-yield capped mRNA quickly, without compromising integrity. With TriLink’s new CleanCap® AG (3′ OMe) CleanScript™ IVT Kit, you can now streamline your entire workflow.

This all-in-one system combines co-transcriptional capping, CleanScript™ chemistry, and CleanScribe™ RNA polymerase, bringing you >95% cap 1 efficiency, up to 10mg/mL yield, and 85% less dsRNA, all in a single-tube reaction.

And now, Tebubio is making it easily accessible across Europe.

Inside the Kit: Everything You Need in One Step

Each CleanCap IVT kit provides everything you need for successful capped mRNA synthesis, optimized for both performance and ease-of-use:

  • CleanCap® AG (3′ OMe): Delivers cap 1 structures with >95% efficiency
  • CleanScript™ IVT reagents: Proprietary buffers and formulation for maximum yield
  • CleanScribe™ RNA polymerase: Engineered to reduce dsRNA up to 85%
  • Modified and unmodified NTPs: Optional N1-methylpseudouridine included
  • Control DNA template
  • Format: 25 × 100µL or 125 × 20µL reactions
  • Yield: ~20–25mg of capped mRNA per kit

Key Benefits:

  • Faster results: Save time with a single-tube reaction
  • Higher integrity: Fewer handling steps means reduced risk of degradation
  • Better performance: CleanCap AG (3′ OMe) enables stronger protein expression with less immune response
  • Less variability: Engineered enzymes provide consistent, reproducible output

Performance at a glance:

  • Up to 10mg/mL RNA
  • >95% cap 1 efficiency
  • Up to 85% lower dsRNA
  • Ideal for therapeutic applications and in vivo studies

 

 

 

Why Scientists Are Switching to Co-Transcriptional Capping

Traditional mRNA workflows often involve complex post-transcriptional enzymatic steps, adding time, costs, and risk. Co-transcriptional capping with CleanCap technology simplifies this by combining the transcription and capping into one streamlined reaction.

 

Powered by CleanCap® and CleanScript™ – A Trusted Innovation

TriLink’s CleanCap technology is a trusted name in mRNA research and therapeutic development. The new kit brings together three of their most powerful innovations:

  • CleanCap® AG (3′ OMe): Efficiently generates biologically relevant cap 1 structures
  • CleanScript™ IVT system: Optimized buffers and components to maximize yield
  • CleanScribe™ RNA Polymerase: Reduces dsRNA for safer, cleaner mRNA

Tebubio: Your European Partner for mRNA Research

As TriLink’s official EU distributor, Tebubio offers more than access: we provide expert support and local convenience:

  • Scientific Expertise: Our team understands IVT and mRNA synthesis at every level. Need help designing the right protocol, selecting the optimal reagents, or troubleshooting yields? We’re here to advise.
  • Faster Delivery: Order directly through our webshop with fast delivery across Europe.
  • One-on-One Support: Talk directly to scientists, not just sales. We help researchers every day make informed product decisions.
  • Regulatory Insight: Whether you’re working on RUO, preclinical, or GMP-grade transitions, we help navigate the right path.

 

Diana Perrier, Marketing Manager

Marketing Team at Tebubio

"Researchers across Europe are already moving to the CleanCap IVT Kit for faster, more reliable mRNA synthesis. With higher yields, cleaner transcripts, and a dramatically simplified protocol, it’s the smartest choice for modern mRNA production."


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Ready to Elevate Your mRNA Workflow?
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  • References

    Article content created by Tebubio using courtesy materials provided by TriLink Biotechnologies.

Knowledge Resources – Expand Your Expertise

Stay at the forefront of mRNA research with Tebubio’s latest insights about TriLink’s products. Read our blogs:

Ready to take the next step?

Not sure which products suits your research best? Our scientific team is here to help! From product selection to Contract Research Services (CRS), we provide expert guidance tailored to your research project needs.