


New CleanCap® AG (3′ OMe) CleanScript™ IVT Kit now available:
Discover the new CleanCap® AG (3′ OMe) CleanScript™ IVT Kit from TriLink, now available at Tebubio.
Achieve high-yield, low-dsRNA mRNA synthesis in a single reaction, powered by CleanCap® technology and backed by our expert European support.
A Simpler, More Powerful Way to Synthesize Capped mRNA
Researchers working in mRNA therapeutics and vaccines know the pressure: deliver high-quality, high-yield capped mRNA quickly, without compromising integrity. With TriLink’s new CleanCap® AG (3′ OMe) CleanScript™ IVT Kit, you can now streamline your entire workflow.
This all-in-one system combines co-transcriptional capping, CleanScript™ chemistry, and CleanScribe™ RNA polymerase, bringing you >95% cap 1 efficiency, up to 10 mg/mL yield, and 85% less dsRNA, all in a single-tube reaction.
And now, Tebubio is making it easily accessible across Europe.
Inside the Kit: Everything You Need in One Step
Each CleanCap IVT kit provides everything you need for successful capped mRNA synthesis, optimized for both performance and ease-of-use:
- CleanCap® AG (3′ OMe): Delivers cap 1 structures with >95% efficiency
- CleanScript™ IVT reagents: Proprietary buffers and formulation for maximum yield
- CleanScribe™ RNA polymerase: Engineered to reduce dsRNA up to 85%
- Modified and unmodified NTPs: Optional N1-methylpseudouridine included
- Control DNA template
- Format: 25 × 100 µL or 125 × 20 µL reactions
- Yield: ~20–25 mg of capped mRNA per kit
Key Benefits:
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Performance at a glance:
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Why Scientists Are Switching to Co-Transcriptional Capping
Traditional mRNA workflows often involve complex post-transcriptional enzymatic steps, adding time, costs, and risk. Co-transcriptional capping with CleanCap technology simplifies this by combining the transcription and capping into one streamlined reaction.
Powered by CleanCap® and CleanScript™ – A Trusted Innovation
TriLink’s CleanCap technology is a trusted name in mRNA research and therapeutic development. The new kit brings together three of their most powerful innovations:
- CleanCap® AG (3′ OMe): Efficiently generates biologically relevant cap 1 structures
- CleanScript™ IVT system: Optimized buffers and components to maximize yield
- CleanScribe™ RNA Polymerase: Reduces dsRNA for safer, cleaner mRNA
Tebubio: Your European Partner for mRNA Research
As TriLink’s official EU distributor, Tebubio offers more than access: we provide expert support and local convenience:
- Scientific Expertise: Our team understands IVT and mRNA synthesis at every level. Need help designing the right protocol, selecting the optimal reagents, or troubleshooting yields? We’re here to advise.
- Faster Delivery: Order directly through our webshop with fast delivery across Europe.
- One-on-One Support: Talk directly to scientists, not just sales. We help researchers every day make informed product decisions.
- Regulatory Insight: Whether you’re working on RUO, preclinical, or GMP-grade transitions, we help navigate the right path.

"Researchers across Europe are already moving to the CleanCap IVT Kit for faster, more reliable mRNA synthesis. With higher yields, cleaner transcripts, and a dramatically simplified protocol, it’s the smartest choice for modern mRNA production."
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References
Article content created by Tebubio using courtesy materials provided by TriLink Biotechnologies.
Knowledge Resources – Expand Your Expertise
Stay at the forefront of mRNA research with Tebubio’s latest insights about TriLink’s products. Read our blogs:
Ready to take the next step?
Not sure which products suits your research best? Our scientific team is here to help! From product selection to Contract Research Services (CRS), we provide expert guidance tailored to your research project needs.