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Empowering Your Research with Proven Quality and Consistency

At Tebubio, we know that reliability and reproducibility are at the heart of every successful experiment. That’s why we offer Cholera toxin products from List Labs, trusted by researchers worldwide for their exceptional purity, stability, and performance across neurological, immunological, and drug discovery studies.

Backed by over 5,000 scientific publications, List Labs’ Cholera toxin range provides you with consistent, validated reagents to accelerate your discoveries.

Description

Formulation

Abbreviation

Reference

Cholera Toxin

 Azide Free

CT

461100B

Cholera Toxin B Subunit (Choleragenoid)

In low salt

CTB

461104

Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate

-

CTB FITC

461106

Cholera Toxin B Subunit Biotin

-

CTB Biotin

461112

Anti-Cholera Toxin B Subunit (Goat)

-

Goat Anti-CTB

461703

Understanding Cholera Toxin

Vibrio cholerae is a highly motile, gram-negative bacterium shaped like a curved or straight rod with a single polar flagellum (Figure 1). It is typically found in brackish or salt water and can inhabit humans, aquatic plants, shellfish, and fish. The bacterium produces Cholera toxin (CT, 84 kDa), a classical AB-type toxin.

  • The A subunit acts as a potent activator of adenylate cyclase, leading to ion and water secretion from mucosal cells and producing the characteristic symptoms of cholera.
  • The B subunit (CTB) binds specifically to GM1 ganglioside receptors on mammalian cells. While non-toxic, CTB elicits a strong humoral immune response and has become a powerful research tool (Figure 2).
Figure 1: Vibrio cholerae.  Figure 2: Structure of Cholera toxin.

 

Applications

 

1. In Neurological Research

Cholera toxin B subunit (CTB) is widely used as a retrograde neuronal tracer, providing highly reliable mapping of neural pathways.

Through its binding to GM1 receptors and internalisation, CTB is transported retrogradely from the site of injection to the neuron’s cell body, enabling detailed imaging and pathway analysis (Fig. 3).
It can also be used anterogradely, tracing transport from the cell body to synaptic terminals.

 

Applications include:

  • Tracing nerve pathways using CTB and GM1 binding

  • Immunohistochemical labelling with anti-CTB antibodies

  • Use of FITC- or biotin-labelled CTB for fluorescence and affinity-based detection

 

Figure 3: Neural tracing model using cholera toxin B subunit.

 

2. Allergy and Immunology Research

In immunological studies, Cholera Toxin (CT) and its B subunit (CTB) are recognised as potent mucosal adjuvants, capable of stimulating targeted immune responses.

Case Study:
When co-administered with a target antigen, CT or CTB enhances mucosal immunity, a property that makes them valuable in vaccine development and food allergy models.
In murine models, these components are used to induce sensitisation to specific food allergens via oral or intraperitoneal administration (Figure 4).

Applications include:

  • Vaccine development studies

  • Food allergy model research

Figure 4: Administration of Cholera Toxin/Cholera Toxin B

 

3. Drug Screening

Cholera toxin is also an essential model compound in studies exploring anti-secretory and anti-diarrhoeal mechanisms.

Case Study:
By inhibiting chloride secretion in intestinal cells (Figure 5), researchers can assess the efficacy of candidate compounds with potential therapeutic benefits.
These include:

  • Fungus-derived molecules

  • GM1 ganglioside-like peptide decoys bound to nanoparticles

  • Natural compounds such as piperine, extracted from black pepper

Figure 5: Inhibition of chloride secretion by cholera toxin.

Our Cholera Toxin Product Range

Description

Formulation

Abbreviation

Reference

Cholera Toxin

 Azide Free

CT

461100B

Cholera Toxin B Subunit (Choleragenoid)

In low salt

CTB

461104

Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate

-

CTB FITC

461106

Cholera Toxin B Subunit Biotin

-

CTB Biotin

461112

Anti-Cholera Toxin B Subunit (Goat)

-

Goat Anti-CTB

461703

Uncompromising Quality and Lot-to-Lot Consistency

List Labs’ manufacturing process ensures the highest standards of consistency and purity, giving you confidence in your results.

Specifications include:

  • Physical appearance: uniform, particulate-free after reconstitution

  • Purity: ≥ 90 % (CT) and ≥ 95 % (CTB) verified by SDS-PAGE and native gels

  • Residual endotoxin: very low

These standards translate directly into reproducible performance and data reliability across experiments.

Trusted Worldwide

With a long-standing reputation for excellence, List Labs products have been cited in more than 5,000 scientific publications, highlighting their reliability across academic and pharmaceutical research.

Accelerate Your Research with Proven Tools

Contact us today to discuss your project needs, obtain detailed specifications, or arrange a bulk supply tailored to your specific study requirements.

Agnès Marcilly, MSc

Marketing Team at Tebubio

"Providing high-purity cholera toxin from List Labs reflects our commitment to supporting reproducible, high-quality autoimmune model research. At Tebubio, we go beyond supplying reagents; we help scientists turn ideas into impactful discoveries."

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  • References

    Image: Courtesy of List Labs, your trusted supplier for cholera toxin.

Discover How Tebubio Brings You High-Purity Cholera Toxin

Tebubio now brings you high-purity Cholera toxin from List Labs, a trusted, activity-tested reagent for reliable use in neurological, immunological, and drug screening research.
With expert scientific support and fast access to multiple validated formulations, we make it easy to integrate Cholera toxin into your neurobiology, vaccine development, or gastrointestinal research workflows.