Streamlining ADC Development with Trusted Reagents
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Antibody–drug conjugates (ADCs) represent one of the most promising frontiers in targeted cancer therapy. At the heart of every ADC lies a finely tuned linker, the molecular bridge connecting a monoclonal antibody to its potent therapeutic payload. The performance, stability, and safety of your ADC depend critically on the chemistry of this linker. At Tebubio, we understand the challenges researchers face when designing ADCs that are both stable in circulation and effective upon delivery. That’s why we’ve brought together a comprehensive range of high-quality ADC linkers and payloads from BroadPharm, enabling you to streamline discovery and development with confidence. |
Linkers: The Key to ADC PerformanceAn optimally engineered linker ensures the antibody delivers its cytotoxic payload precisely at the tumour site, maintaining stability through manufacturing, storage, and systemic circulation. Enhanced linker stability helps prevent premature drug release, improving safety and enabling lower, more effective dosing regimens (Figure 1). ADC linkers fall broadly into two categories:
Explore our curated selection of linkers designed to meet the exact needs of your research. |
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Cleavable Linkers
Stable in circulation and responsive within tumour cells, cleavable linkers ensure payload release only where it’s needed. Options include enzymatically cleavable peptide linkers, Acid-sensitive hydrazone linkers and Glutathione-sensitive disulfide linkers.
Each variant offers distinct benefits in terms of stability, release kinetics, and application suitability, empowering you to design ADCs with optimal therapeutic indices.
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Site-Specific Linkers
Our site-specific linkers enable precise coupling of cytotoxins or chemotherapeutic drugs to defined sites on antibody molecules. This precision promotes higher homogeneity and improved therapeutic index (TI).
Beyond classical ADCs, these linkers support next-generation immunoconjugates, offering enhanced efficacy and safety across a broad range of disease models.
Examples include:
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PEG Linkers
PEG linkers (polyethylene glycol-based) are versatile tools for conjugation, drug discovery, nanoparticle delivery, and biolabelling. Their hydrophilicity and non-immunogenicity make them particularly attractive for a wide array of bioconjugation strategies.
We offer over 10,000 PEG linkers, available in multiple functional formats (e.g., amino, azido, alkyne, NHS ester). Browse our full collection to find the right molecular weight and functionality for your application.
Example of popular PEG Linkers:
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ADC Payloads
The payload defines the ADC’s therapeutic power. Tebubio provides access to a diverse selection of research-use ADC payloads, including:
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Tubulin inhibitors (Auristatin, Maytansine, Tubulysin)
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DNA-damaging agents (Calicheamicin, Duocarmycin, IGN)
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Immunomodulators (STING agonist, TLR8 agonist, TLR9 agonist)
Each payload can be conjugated through cleavable or non-cleavable linkers to suit your desired mechanism of release.
Other research-use payloads include: MMAE, MMAF, Maytansinoid, DM3, DM4, Eribulin, Paclitaxel, Doxorubicin, SN38, Deruxtecan, Camptothecin.
Advanced Linker Systems
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β-Glucuronide Linkers: enzyme-labile, stable in circulation, and highly active in vitro and in vivo (Glucuronide, Sophoricoside)
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Disulphide Linkers: selectively cleaved in reducing intracellular environments (Aminoethyl-SS, Amino-SS-PEG, Azidoethyl-SS, Azido-SS PEG, Azidoethyl-PEG, Propargyl-PEG, DBCO-S-S, 4-Azide-TFP, Acid-PEG-SS, SPDP)
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Dual Payload Linkers: engineered to carry two payloads (identical or distinct) in a single conjugate (MMAE, Exatecan, Doxorubicin)
Partner with Tebubio
Our goal is simple: to make your ADC development faster, more reliable, and scientifically robust.
At Tebubio, we connect you with validated reagents, innovative chemistries, and technical expertise — so you can focus on advancing discovery, not sourcing components.
- Explore our full ADC product portfolio
- Contact our scientific support team for guidance or custom requests
Agnès Marcilly, Digital Campaign Specialist
Marketing Team at Tebubio
"At Tebubio, we empower scientists to design smarter, safer, and more effective ADCs by providing the precise linkers and payloads that turn complex ideas into clinical potential."
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References
Article content created by Tebubio using courtesy materials provided by TriLink Biotechnologies.
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