Page 2 - Scientific Library

DNA methylation and histone post-translational modifications are key epigenetic factors.

They regulate

Histone-lysine N-methyltransferase EZH2  is a methyltransferase involved in transcriptional gene regulation. Together with with EED, RbAP48, SUZ12 and AEBP2, EZH2 forms a 5-member complex that adds 3 methyl

Nucleosomes are core particles involved in DNA packaging in eukaryotic cells. They affect gene expression levels  by regulating access of DNA to transcription factors and DNA binding proteins. Nucleosome

In the summer of 2013, my colleague Frederic Dubor, who is in charge of our services lab, mentioned to me that he had just been asked by 3 clients within a very short time-frame, whether our laboratory

Recombinant Histone proteins are popular research solutions in Drug discovery and Epigenetics studies. They can be used as in vitro positive controls in the analysis of post-translational Histone

Epigenetic modifications target DNA and Histone proteins.

One of the roles of Epigenetics is to drive cellular differentiation from totipotent Stem cells to fully differentiated cell types, by regulating

The Histone Demethylase FBXL10 (also known as NDY1, KDM2B, or JHDM1B) has been reported to demethylate histone H3K4me3.  By removing active Methyl Epigenetic marks on the chromatin, this "Epigenetic Eraser"

DNA and Histone proteins are targets for epigenetic modifications.

One of the roles of Epigenetics is to drive cellular differentiation from totipotent Stem cells to fully differentiated cell types,

A lot of efforts are made to identify potent and selective inhibitors for the demethylation reactions catalyzed by members of the JMJD2 and JARID1 protein families (1, 2). Both