Biotinylated Anti-PtdIns(3 4 5)P3 IgM - 50 ug

Purified Anti-PtdIns(3 4 5)P3 monoclonal antibody conjugated with biotin.Subclass: IgMSource: MouseApplications: ImmunofluorescencePhosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2. Powered by Bioz See more details on BiozProduct keywords: PIP3 PI(3 4 5)P3 PtdIns(3 4 5)P3 IgM anti-PIP3