Biotin PI(3 4 5)P3 - 50 ug

Biotin PI(3 4 5)P3 (Biotin Phosphatidylinositol 3 4 5-trisphosphate) is a water soluble analog of PI(3 4 5)P2 (PIP3) labeled with biotin at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3 4 5-trisphosphate (PIP3) formed from PI(4 5)P2 though phosphorylation by PI 3-kinase activates numerous signaling pathways resulting in cell proliferation growth survival glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4 5)P2 and SHIP to PI(3 4)P2.Featured in Publications1. Anzelon A. N. H. Wu et al. (2003). "Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function." Nat Immunol 4(3): 287-94.2. Bidlingmaier S. et al. (2011). "Comprehensive analysis of yeast surface displayed cDNA library selec