Beta Amyloid (1-42) human - 1 mg

CAS Number: 107761-42-2Molecular Weight: 4511.3Salt Form: TFAPurity: >95%Sequence (3-letter): Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OHSequence (1-letter): DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OHStorage: -20 °C or belowSolubility: 1 mg/mL in 50 mM Tris or dissolve 1 mg in 70-80 uL 1% NH4OH then dilute to 1 mg/mL with 1X PBS. Do not store in 1% NH4OH dilute immediately with PBS.Beta amyloid (1-42) is the predominant form of β-amyloid protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome. Beta amyloid down-regulates bcl-2 (a key anti-apoptotic protein) and upregulates bax (cell death promoter) with evidence suggesting that it renders neurons vulnerable to age-dependent stress and neurodegenerationReferences Powered by Bioz See more details on Bioz1. Scheuner D. et al (1996) “Secreted amyloid bold beta−protein